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Archive for Drugs & Pediatrics

Here you can read the news selection on Drugs & Pediatrics in the Children Health category.

Children’s Suicide Attempts Raise Concerns about ADHD Medication

New questions are being raised about the safety of a drug used to treat attention-deficit hyperactivity disorder amid reports that more than 40 Canadian children have attempted suicide after taking it.

The issue highlights a long-brewing debate over the decision to prescribe powerful drugs to treat complex psychiatric problems among children.

“It does raise some concerns,” said Roger McIntyre, head of the Mood Disorders Psychopharmacology Unit at Toronto’s University Health Network.

“Childhood psychiatric disorders, I think, are an area [that] in and of itself remain a controversial topic.”

Health Canada said it received 189 reports of adverse reactions associated with atomoxetine, sold under the name Strattera, from the time it was put on the market in February, 2005, to the end of last year.

The reports included 55 suicide attempts - 41 of which were among children aged 6 to 17, and 12 that were adults between 18 and 45. Ages were unavailable in two reports, according to information published by Health Canada in its quarterly publication on adverse drug reactions.

Of the 55 suicide attempts, one patient died, three had not yet recovered, and 29 had recovered. The outcome was unknown in 22 reports.

It is not the first time concern has been raised about Strattera, and other ADHD drugs. In September, 2005, just months after the drug was put on the Canadian market, Health Canada warned that the drug may trigger behavioural changes or increase the risk of self-harm. A year later, it issued a warning that all ADHD drugs may be associated with agitation, hallucinations and other psychiatric problems among children.

One expert said the problems associated with this category of drugs should prompt serious questions about the fact they are often prescribed to young people with ADHD.

“The drugging of children for attention-deficit disorders is very controversial,” said Alan Cassels, a drug policy researcher at the University of Victoria. “You might say, ‘Why is this being prescribed at all?’ “

Another serious issue is the fact many parents, and even some doctors, may be unaware that certain drugs have been associated with problems, Mr. Cassels said. That’s because such warnings are often not well publicized and may not reach the ears of parents who must make the crucial decision about whether to put their child on powerful medications.

“If you’re a parent and your kid gets prescribed Strattera, do you know that drug comes with a risk of attempted suicide?” he said.

Many children may require medication to manage the symptoms of ADHD, according to Dr. McIntyre, who is also a psychiatry and pharmacology professor at the University of Toronto. But such disorders often coincide with other underlying psychiatric conditions that have not yet been recognized or diagnosed. As a result, ADHD medication could inadvertently trigger a suicidal reaction or other severe behavioural problems, he said.

It’s important for parents to inform themselves about the risks of a particular drug so they can look for any warning signs, Mr. Cassels said.

Eli Lilly Canada, which makes Strattera, declined to provide a spokesperson to respond to questions yesterday. But the company provided a written statement saying that Strattera is not the only stimulant-type ADHD treatment that has been associated with behaviours related to suicide. The company said more than five million people worldwide have taken the drug since it was approved.

“Lilly continues to actively monitor and evaluate all new safety data sources as they become available, and will take prompt and appropriate action based on new findings in accordance with established risk-management principles,” communications manager Jennifer Gordon said in a statement.

Source: Globe and Mail, Canada
http://tinyurl.com/6yysff

4 July, 2008. 9:08 PM. Link | Comments: No Comments »

Children Labelled Hyperactive Really ‘Just Naughty’

Teachers are misdiagnosing some children with attention deficit hyperactivity disorder when they are just naughty, psychiatrists have warned.

Only half of children teachers suspected of having ADHD were diagnosed with the condition by a mental health expert, a study found.

The results of the study carried out in East London will be presented at the annual meeting of the Royal College of Psychiatrists.

Children with ADHD cannot concentrate on school work or play and are easily distracted, forgetful or fail to follow instructions.

They also unduly noisy, restless and fidget constantly and often talk excessively, butt in to other’s conversations and cannot wait in line.

Estimates suggest that around 1.7 per cent of the population is affected by ADHD, mostly children and if it cannot be controlled with behavioural therapy then medication such as Ritalin is considered.

In the study, based in Tower Hamlets, 52 children were referred to the Child and Adolescent Mental Health Services team with ADHD-like symptoms over the course of one year.

Of those, it was clear most did not have ADHD and 14 were observed in the classroom by the mental health team. Eventually six were diagnosed with ADHD.

The researchers said that they are unsure why teachers may be over-identifying children with possible ADHD diagnoses.

Lead author Dr Benjamin Keene, said: “Naughty children may at some point present symptoms but someone with ADHD has them at all times.”

They suggest that better educational resources need to be made available to teachers to help them accurately identify those children with ADHD, and that CAMHS teams should develop structured school observation tools or telephone interview schedules, so that identified children can be independently and expertly assessed in a classroom setting.

Source: Telegraph.co.uk, United Kingdom
http://tinyurl.com/6l74sw

4 July, 2008. 9:02 PM. Link | Comments: No Comments »

Computer Games to Help Kids with ADHD

Computer games may have received a bad rap for fostering behavioural problems among young children, but one child psychologist has discovered some games have therapeutic benefits.

Andrew Campbell, a lecturer in psychology with the University of Sydney, has been researching ways to treat ADHD with therapeutic computer games. His ground-breaking research recently caught the attention of a major Singaporean gaming company, which is about to finalise a contract to fund an “e-lab” at the university.

Dr Campbell and PhD student Krestina Amon have discovered that an off-the-shelf computer game - in which the player wears bio-feedback sensors, and must use breathing and meditation techniques to advance through the levels - can markedly improve the stress and concentration levels of ADHD sufferers.

Now the international gaming company Nexon has agreed to fund Dr Campbell’s research and develop an e-lab within the University of Sydney’s Faculty of Health Sciences.

Together they plan to develop new therapeutic computer games that could increase self-esteem, reduce anxiety and help children manage ADHD.

“Nexon believes there is a whole new market for therapeutic games that deliver real outcomes, and we’ll provide the science,” Dr Campbell said.

The child psychologist hopes this treatment will offer parents an alternative to controversial stimulant medications used to treat ADHD.

“We’re not saying this is the holy grail of ADHD treatment, but our research has shown that therapeutic games can improve the concentration of those with mild or moderate ADHD.”

Source: The Australian, Austalia
http://www.theaustralian.news.com.au/story/0,25197,23869261-23289,00.html

16 June, 2008. 2:32 PM. Link | Comments: 1 Comment »

Drugs for Toddlers? You Must Be Kidding

Somewhere between the traffic report and an erectile dysfunction advertisement, John Deeks booms over your breakfast cereal: “Does your two-year-old make careless mistakes? Do they appear to not be listening to you? Does your son crawl around or climb on things? Or is your daughter easily distracted and babbles excessively?”

“If you answered, ‘Yes’ to most of these questions, your baby is suffering from a common case of ADHD and may be in need of the health benefits of Methylphenidate Hydrochloride.”

Now in handy pop-packs for little fingers, it comes in new Dora The Explorer, The Wiggles and Bob the Builder range, perfect for long car trips, shopping trolley tantrums and special occasions like birthdays and Christmas. Consult your local GP today.”

It’s a mock advertisement, of course, but there are scary parallels to reality as we learned yesterday that more than 300 children in NSW alone are using mind-altering drugs before they have even reached school-age - some while still in nappies.

Take those warning signs. They are the official behavioural patterns issued by the health department if you are concerned your child suffers from attention deficit hyperactivity disorder.

Do the following signs apply to your toddler? Having difficulty sustaining attention, not listening, not following through on instructions, getting easily distracted, fidgeting with hands or feet, won’t remain seated, runs about or climbs excessively, won’t be quiet, talks excessively, “blurts answers before questions have been completed”, difficulty taking turns and interrupting.

Really, is there any other kind of two-year-old? Or three-year-old, even four- or five-year-old? The health department list reads like a review of a Hi-5 concert. These are all babyish behaviours - they have not yet had a chance to prove they know any better.

If all of the above presented in a severe form in an older child, medication might well be an option, but what baby who is still learning to walk, cannot talk, eat, or go to the toilet on their own yet, screams ADHD so desperately they need to be drugged?

You can’t even buy cough mixture for your under two-year-old any more without a prescription. Yet there are at least 311 pre-school children on “kiddy cocaine” such as Ritalin, Concerta, Dexamphetamine and Strattera and a further 58 four-year-olds and 13 three year-olds are also wandering the state like space cadets.

The known side effects of these drugs are sickening when applied to a toddler. Suicidal tendencies, stomach cramps, shortness of breath, heart palpitations, delusions, lack of appetite, nausea, diarrhoea and insomnia.

Narelle King, the mother of a nine-year-old ADHD-diagnosed boy who she says has improved out of sight without medication, said: “It’s appalling. It makes me sick.”

King used the Dore program for her son Lucas, which uses exercises to stimulate the brain without drugs. She was so impressed, after seven months she became program adviser.

While she is “disgusted” by the new figures, she is far from surprised.

“I had a client with a six-month-old who had been prescribed Ritalin. You’ve got to be joking. The baby wasn’t sleeping, it was having trouble settling, and Ritalin is the answer?” she said.

“You’ve got to wonder whether the parents in these cases have exhausted all other options.”

David Hay, who specialises in ADHD at Curtin University, said the figures were too small to be of concern.

“I think the figures are not bad, actually - we’re not doing such a bad job,” Professor Hay said.

“It shows we bend over backwards in Australia to be scrupulous in giving medication to children of this age.”

Stringent the process may be, but we’re talking about a drug that causes children to grow just 2cm in three years - and that’s the older ones.

At best, patients can expect muscle twitching and, at worst, seizures and convulsions. Commonly they experience confusion and hallucinations, sweating, blurred vision, dry mouth and nose, and fainting.

Worse still, a wrong dose can be fatal.

If there are five two-year-olds in the world, let alone Australia, subject to these powerful drugs, it’s five too many.

There has been little research into either the short or long-term effects on the pre-school age group.

At the very least, it warrants further examination - you just don’t mess with the heads of babies.

Source: NEWS.com.au, Australia
http://www.news.com.au/story/0,23599,23781648-5007146,00.html

30 May, 2008. 8:29 AM. Link | Comments: No Comments »

Is your Child Really an ADHD?

An architect friend and I were recently discussing the various schooling options available to his kid who had completed her eighth grade and was moving to the ninth. Two more years, and she would be finishing secondary school already. How time flies!

Time was, when this friend of mine was considered the most mischievous kid in our class in grade six or thereabouts. Nary would a week pass without his parents being called to school for this or that complaint about him. Finally fed up with his antics, the principal asked that the child be moved elsewhere.

Because our families knew each other, we kept in touch somehow, even when we relocated to another city. He struggled in studies, of course, but managed to trundle through school. Later in college, I learnt that he eloped with some girl and got married, as the parents of the two frowned upon the relationship. Life was one huge rollercoaster for this guy! And after a few years, he finally settled down, set up a good architectural practice, and with time had two kids.

The kids giggle - and the mother joins in the mirth - when I recount to them how their father had once hidden a frog in the chalk-box, and how the teacher had the fright of her life when she opened the lid. All through my narration, the proud father would wear a smug smile and a nice halo around him, soaking in the wholesome praise that the family members would lavish!

Wonder therefore, if the friend had been born to parents who were, uh, from a different stock? What if the parents had not let the child grow naturally on his own accord, but had become concerned at the principal’s words, and sought medical intervention for “treating” him?

(The friend’s father actually roared with laughter when the teacher told him about the frog. Clearly, he approved! I suspect the father’s own antics of childhood must have flashed before his eyes in that moment. Some characteristics get carried forward, you know.)

So, what would have happened if the parents had been more paranoid about the child’s behavior being “different” from the rest of us lambs? What would have happened to his natural effervescence, his zest for enjoying other people’s discomfiture at their expense? What would have happened to his excitement about all things new and novel? We all enjoyed his antics - they were quite harmless; actually we looked forward to it, as they were a nice distraction from the usual drab of rote-learning that school used to be those days.

So, wonder what arc his story would have taken, had his parents been, uh, more concerned? Would he have had it in him to summon the courage to execute the romance-and-elopement-and-marriage project? Would he have settled down in life with a balanced head on the shoulders? Would he have been as successful as he is today?

Going by the recent trends in society, how the story arc would have turned out is the parents taking him to the school’s consulting physician. AND this expert labeling the kid “ADHD case”. AND prescribing him the routine medications that an ADHD patient gets prescribed. The medication becomes the MacGuffin of the plot, whose unfolding would from then on be both unpredictable and thrilling. Thrilling as in a psycho-thriller with a nail-biting climax.

His hyperactivity might have transformed into hallucinations, his cheerfulness would have yielded to nervous ticks and irritability, and his creativity would have been replaced by dizziness and depression. Innocent and defenseless, he wouldn’t have been able to rebel. The romance, elopement, the marriage and the two kids wouldn’t have happened. And I wouldn’t have been able to narrate to the family how the frog frightened the life out of the teacher, whose home was ultimately designed by the very same architect she complained against, almost 34 years ago. (At no cost, too, my friend tells me. His style of atonement, he says.)

Not an expert in this domain, my idle mulling stems from the fierce debate one gets to read in the forums and the news, raging between the two powerful lobbies of the pro- and the anti- psychotic-drug-treatment groups. The NIMH says the drugs are quite okay. This news report from BBC says no.

So as parent, who are we to believe? May be an approach which does not involve medication could be the best way to go for the time being? Let the researchers thrash out amongst themselves and decide finally who is right and who is wrong. May the best side win! But let us not be paranoid and change the child’s story arc from successful architect to one with a psycho-thriller climax.

Source: HULIQ, NC
http://www.huliq.com/60434/your-child-really-adhd

28 May, 2008. 7:45 AM. Link | Comments: No Comments »

Five Things New Parents Need to Know

Parents have some homework to do, according to new findings presented at the Pediatric American Society meeting in Honolulu, Hawaii, this weekend.

The research shows that 31% of U.S. parents know very little about the pace of a typical infant’s development, whether it’s when a child should start talking or begin potty training. The data is based on an analysis of the Early Childhood Longitudinal Study’s Birth Cohort, a nationally representative sample of more than 10,000 9-month-old babies and their primary caregivers. Parents were asked to answer 11 questions, where those who got four or fewer correct were considered to have low-level knowledge.

While it may not sound like a big deal, experts say that this lack of knowledge can negatively affect parents’ interactions with their babies.

We asked study author Dr. Heather Paradis, a fellow in pediatrics at the University of Rochester Medical Center, why so many parents don’t know what to expect after expecting and what they need to know about their babies’ development.

Why do so many parents lack knowledge about infant development?

I think that parents get parenting information from a variety of sources, from reading magazines and books … most importantly, parents look for information from their child’s doctors.

There’s a lot of information that’s out there about what to expect when people are pregnant, but I don’t know that there is quite as much information on what to expect about how your child grows and develops in the first years of life, and there’s a tremendous amount of change. This study was surprising in just how many parents don’t have knowledge of normal infant development.

Do you have a sense as to whether this is a new trend?

I think that a lot of emphasis in the past has been placed maybe on what we would call “high-risk” parents–those with a lower education, lower socioeconomic status. But one of the surprising things that this study showed is that it’s not only those parents we should be targeting, but it’s something we should expand to the general population of parents. Everyone could benefit.

What was one of the most surprising things the study revealed in terms of parents’ confusion?

The most surprising thing to me was not necessarily what knowledge they did or didn’t have, but how that knowledge translated into actual behavior, or observed interaction with the child. That connection is something lacking in previous studies. This study showed that parents who have higher knowledge of normal infant development were shown to have higher (quality) observed interactions with their children.

The other thing is that we looked at not only parent/child interaction but parents’ reports of frequency of what I would call enrichment activities, such as reading books with a child, singing songs. We know early enrichment activities with kids leads to higher IQs, earlier reading, better school preparation. The parents with the higher knowledge of normal infant development also had a significantly higher reported frequency of doing those enrichment activities with their kids.

What are the potential negatives?

Parents who have unrealistic expectations could misinterpret a child’s normal behavior and could respond inappropriately. An example would be like a mom who expects an 18-month-old child to sit still during an appointment. Eighteen-month-olds are normally curious. I would expect them to be wandering around the room. If parents are expecting a child to sit still on a chair for an entire appointment, they may take normal curiosity and interpret it as intentional defiance, rather than the normal curiosity it is. That could lead to inappropriate harsh discipline or the withdrawal of affection.

I think quite often parents maybe underestimate a child’s ability to pick up language skills. A lot of parents don’t think that it’s worthwhile to read a book to their infant, to their 2-month-old, and they definitely should be doing that, even if it’s to look at pictures and let the child hear the normal qualities of voice. They might not understand the words the parent is saying but they definitely understand what’s going on and the interaction going on between the two of them.

How should parents go about educating themselves?

Certainly, I think it’s an opportunity for pediatricians that, even during our brief office encounters with parents, we can potentially do something that can have a large impact on the way that parents and children interact. I do think that getting information from reputable sources, asking a child’s doctor for recommendations on books and Web sites to get high-quality information, is something parents could do.

Source: Forbes, NY
http://tinyurl.com/68hrk2

4 May, 2008. 10:33 AM. Link | Comments: 1 Comment »

Growing up on Drugs

America’s increased focus on standardized test scores has meant more widespread use of drugs for ADHD—whether kids need ’em or not

Over the past few weeks, many thousands of Georgia elementary and middle school students sharpened their No. 2 pencils and waited for the teacher’s signal to turn over their answer sheets and hunker down to business on the Georgia Criterion Reference Test. Most did so without being under the influence of drugs, but some had been “juiced” for the test well in advance, perhaps even months or years in advance, through the use of drugs prescribed to treat attention deficit hyperactive disorder (ADHD).

Jennifer Fox, author of Your Child’s Strengths: Discover Them, Develop Them, Use Them, has seen the phenomenon herself. Fox, who is president of The Purnell School, a boarding school in New Jersey, describes a student she calls “Kate” (not her real name) who was extremely effervescent. She smiled a lot. She laughed a lot. She played a lot, even in class. Teachers complained that she wasn’t focused, so her parents had her put on a drug that was supposed to treat ADHD, and she lost that bubbly personality. It was as if the life “had been sucked out of her.”

“Kids are rushed to get diagnosed as learning-disabled so they can get extra time on tests and they can get put on drugs to perform better on tests,” says Fox, who is scheduled to sign her book at Wordsmiths in Decatur on Wednesday, April 30. “What we have in this country is a system that puts kids on drugs and gets them hooked on drugs for the rest of their lives.

Though Fox acknowledges that there are children who definitely need medication, the problem, as she sees it, is an unhealthy focus on standardized test scores—a focus that parents often share with teachers, one that puts performance ahead of a child’s health and well-being.

“The schools are failing. The standardized tests are failing. And we are putting kids on drugs to try to overcome that,” she says. “That, to me, is like child abuse in a way.”

Fox points out that “Kate” had a strong suit—that bubbly personality that the drug erased. She says that she envisioned Kate someday working in a profession that required that kind of energy and vivaciousness. But since that strength was drugged out of her, who knows if Kate will ever make the most of the gift that she naturally had? Though Fox admits that there are kids who need medication to treat ADHD and other disorders, she adds, “I believe that it may be that these drugs are getting rid of the very thing that is best about these kids, something unique that the world needs.”

“Before You Take That Pill”

In his book Before You Take That Pill: Why The Drug Industry May Be Bad For Your Health, which hit bookstores in March, J. Douglas Bremner, a professor of psychiatry at the Emory University School of Medicine, explains that although its exact causes are not known, some scientists think that ADHD is related to alterations in the brain chemical dopamine, which modulates attention. Nonetheless, he views with skepticism the popularity of a plethora of stimulants used to treat ADHD, including Ritalin, Adderall and, a slow-release version of Ritalin, Concerta.

In his book, Bremner writes: “An entire generation of kids who cannot pay attention is being diagnosed more and more frequently (and sometimes inaccurately) with Attention Deficit Hyperactivity Disorder, or ADHD. It seems strange that it has been increasing so dramatically over the past few years. Certainly in the last generation many children with concentration problems were simply labeled unintelligent or ‘problem kids.’ However, with current competition for children to excel in school having reached such a fever pitch, it is no longer acceptable to let children fall behind. The elimination of recess, the lengthening of the school year, and the insistence that children remain rigidly fixed in their chairs without making a peep flies in the face of the realities of normal childhood.”

Bremner cites a three-fold increase in Ritalin prescriptions in the four years between 1991—which just happens to be the year that the U.S. Congress agreed that an ADHD diagnosis should qualify children for extra time on tests—and 1994. He goes on to point out that fully 10 percent of boys in America are prescribed some kind of stimulant for ADHD or other mental conditions.

On a recent weekday morning, Bremner, a soft-spoken man with a reserved demeanor, balances a laptop across his knees at a coffee shop, accepts an offered cheese cracker and explains his skepticism: “Do all of the kids who are taking Ritalin meet the requirements for ADHD? Probably not.

There are reasons, not necessarily medical, that children might be prescribed a drug for ADHD, Bremner says. It may be that their parents want them to perform better in school, and those parents can pressure a doctor who is already pressured by pharmaceutical sales reps to write the prescription. It may also be the case that the child’s tendency to, well, be a child, is a problem.

“What we do know about these drugs and playfulness,” he says, “is that they tend to decrease playfulness.”

But how and why the drugs get prescribed isn’t the concern of the drug companies. The job of drug companies, he says, is not to make people well, but to sell drugs, and it’s a job that they do very, very well. Children, in particular, can provide a business boon, because once they’re on a drug, at what point is it OK to take them off? “Before You Take That Pill,” explores the risks of a wide range of drugs—not just those prescribed to children—and begins with the startling revelation that “Now, more than half of all Americans are taking a prescription drugs.

All of the amphetamine-like stimulants used to treat ADHD, writes Bremner, act as appetite suppressants, and therefore may impede a child’s growth. They also “have been linked to approximately a doubling of heart-related deaths in children.” Such deaths are still rare, however. What he would like to see, Bremner says, is a little more skepticism on the part of Americans toward the extremely profitable drug companies.

Watching cartoons and drug commercials

Don’t count on the current crop of kids to be the ones to develop that skepticism. Rick McDevitt, executive director of the Georgia Advocacy for Children, says that drug use to solve problems has become an assumed part of American life, beginning when children are plopped in front of a television, where they view one pharmaceutical commercial after another. At school, he says, they are given to understand that if they do not do well on standardized tests, there might be something wrong with them that a drug can fix. Teachers tell parents their child isn’t focused and that they should seek help, and “help” turns out to be “take these pills.”

The drugging of kids has become commonplace, the drug is a means of social control and the schools have become agents of that social control,” McDevitt says. “It’s about the test scores, it’s not about solving the problems at the source. The kids take the drugs, the test scores are better, and everyone says ‘They’re doing better.’ They’re not doing better. They are on drugs.”

Local child psychologist Sunaina Jain was listening to the radio recently when she happened upon a on a show on which people were talking about “our child-obsessed society.”

“I thought ‘What child-obsessed society?’ We don’t even like children in this society,” she says. “We do everything we can to make them become adults quickly.”

Jain, who has been in practice since before Ritalin hit the market in the late 1980s, says that the enormous use of drugs to treat ADHD is one more symptom of the need to make children become grown-ups. Although such drugs have helped many children, she says there is little doubt that they are over-prescribed. ADHD, she explains, affects about one boy in15 and girl in 25, but the number of prescriptions would seem to suggest that ADHD is epidemic in the United States.

Part of the problem is parents who are looking for a way to improve their children’s test scores,” says Jain. “For these parents, these are ‘showcase’ children—their children’s success reflects on them. They want success, they want good grades, and if that can be obtained by popping a pill, that is what they do. There are also kids whose parents just don’t have time to pick them up from school and help them with their homework.

The tendency to resort to drugs, she says, cuts through all economic classes. Like Fox, Bremner, and McDevitt, she points to a culture that makes it tough to be a kid. It’s a problem that affects the poor and the rich, though in different ways.

If you have nanny-raised kids, you have the same problem that you have with poor, disadvantaged kids. With a nanny, they are not getting what they would from parents—they don’t learn how to connect with people,” Jain says. “Our strongest need is to connect with other human beings, and if you don’t learn how to do that, that’s a problem.”

The complaint she hears most from parents and teachers goes a long way in explaining what’s going on: “I don’t have time for this.”

The view of childhood as a time when competition makes or breaks one, as a screening process for winners and losers that needs to be gotten out of the way in time to join the adult world, is a view that distorts the children. Jain says the situation of children in America has steadily deteriorated since the 1980s. She believes that as a country, we have shifted away from seeing childhood as “practice” for adulthood and more as the game itself.

“But you know, you need practice to be good at the game,” she says. “A kid needs a coach, someone to say, ‘this is how you hold the bat.’ Then, after thousands of practices, one day they’re ready to go out into the world, to the game. A drug can’t tell them how to hold the bat.”

Source: Sunday Paper, GA
http://tinyurl.com/3o777x

28 April, 2008. 9:06 AM. Link | Comments: No Comments »

Children with ADHD Should Get Heart Tests before Treatment with Stimulant Drugs

Children with attention deficit hyperactivity disorder (ADHD) should get careful cardiac evaluation and monitoring – including an electrocardiogram (ECG) – before treatment with stimulant drugs, a new American Heart Association statement recommends.

The scientific statement on Cardiovascular Monitoring of Children and Adolescents with Heart Disease Receiving Stimulant Drugs is published online in Circulation: Journal of the American Heart Association.

In 1999, concerns over potential cardiovascular effects of psychotropic drugs, especially tricyclic antidepressants, but including stimulants, prompted an American Heart Association Scientific Statement: Cardiovascular Monitoring of Children and Adolescents Receiving Psychotropic Drugs. However, no specific cardiovascular monitoring was recommended for the use of stimulant medications. Warnings from the U. S. Food and Drug Administration (FDA) about stimulant medications and public concern for the safety of using them have prompted the current statement.

Studies have shown that stimulant medications like those used to treat ADHD can increase heart rate and blood pressure. These side effects are insignificant for most children with ADHD; however, they’re an important consideration for children who have a heart condition. Certain heart conditions increase the risk for sudden cardiac death (SCD), which occurs when the heart rhythm becomes erratic and doesn’t pump blood through the body.

Doctors usually use a physical exam and the patient and family history to detect the risk for or presence of health problems before beginning new treatments, including prescribing medication. But some of the cardiac conditions associated with SCD may not be noticed in a routine physical exam. Many of these conditions are subtle and do not result in symptoms or have symptoms that are vague such as palpitations, fainting or chest pain.

That’s why the statement writing group recommends adding an ECG to pre-treatment evaluations for children with ADHD. An ECG measures the heart’s electrical activity and can often identify heart rhythm abnormalities such as those that can lead to sudden cardiac death.

“After ADHD is diagnosed, but before therapy with a stimulant or other medication is begun, we suggest that an ECG be added to the pre-treatment evaluation to increase the likelihood of identifying cardiac conditions that may place the child at risk for sudden death,” said Victoria L. Vetter, M.D., head of the statement writing committee and Professor of Pediatrics at the University of Pennsylvania School of Medicine in Philadelphia.

Vetter also said doctors should evaluate children and adolescents already taking these medications if they were not evaluated when they started the treatment.

If heart problems are suspected after the evaluation, children should be referred to a pediatric cardiologist. Once stimulant treatment begins, children should have their heart health monitored periodically, with a blood pressure check within one to three months, then again at routine follow-ups every six to 12 months.

“Children can have undiagnosed heart conditions without showing symptoms,” Vetter said. “Furthermore, a child’s body changes constantly, with some conditions not appearing until adolescence.”

If the initial ECG was taken before age 12 years, it may be useful to do a repeat ECG after the child is over age 12 years, the statement says.

Widespread use of ECGs to detect heart abnormalities, including screenings for competitive athletes, is not routinely recommended by the American Heart Association. However, the writing group found using ECG screening in this specific population of children prescribed ADHD medication is medically indicated and reasonably priced. That said, however, lack of an ECG shouldn’t mean that kids who need ADHD treatment can’t get it.

“While we feel that an ECG is reasonable and helpful as a tool to identify children with cardiac conditions that can lead to SCD, if, in the view of their physician, a child requires immediate treatment with stimulant medications, this recommendation is not meant to keep them from getting that treatment,” said Vetter, who added that some children may not have access to a pediatric cardiologist who can evaluate an ECG or perform a cardiology consultation.

In 2003, an estimated 2.5 million children took medication for ADHD. Surveys indicate that ADHD affects an estimated 4 percent to 12 percent of all school-aged children in the United States, and it appears more common in children with heart conditions. Studies report that, depending on the specific cardiac condition, 33 percent to 42 percent of pediatric cardiac patients have ADHD, Vetter said. The number of undiagnosed children with heart conditions is unknown as routine heart screening is not performed, but Vetter said that a recent pilot study she presented at the American Heart Association’s 2007 Scientific Session indicated that up to 2 percent of healthy school aged children had potentially serious undiagnosed cardiac conditions identified by an ECG.

Data from the FDA showed that between 1999 and 2004, 19 children taking ADHD medications died suddenly and 26 children experienced cardiovascular events such as strokes, cardiac arrests and heart palpitations. Since February 2007, the FDA has required all manufacturers of drug products approved for ADHD treatment to develop Medication Guidelines to alert patients to possible cardiovascular risks.

Future studies are necessary to assess the true risk of SCD in association with stimulant drugs in children and adolescents with and without heart disease, Vetter said. However, studying SCD associated with drugs is difficult because the government’s reporting system is voluntary, which means local data on these types of deaths isn’t always reported nationally.

A registry of SCD events is necessary for further investigating this issue, the writing committee said. Such a registry would allow for a more accurate understanding of SCD, including the true incidence of it and the potential effectiveness of universal ECG testing and pre-participation screening questionnaires.

The statement writing committee said its recommendations are not intended to limit the appropriate use of stimulants in children with ADHD.

“Our intention is to provide the physician with some tools to help identify heart conditions in children with ADHD, and help them make decisions about the use of stimulant medications and the follow-up of children who take them,” Vetter said. “The goal is to allow treatment of ADHD, while attempting to lower the cardiac risk of these products in susceptible children.”

Source: EurekAlert, DC
http://www.eurekalert.org/pub_releases/2008-04/aha-cwa041808.php

22 April, 2008. 9:05 AM. Link | Comments: No Comments »

Adolescents, Alcohol a Dangerous Mix in Austria and across Europe

A 13-year-old schoolgirl in southern Austria celebrated the start of her spring break with a bottle of schnapps.

She ended up in intensive care.

In other countries across Europe, adolescents are making similar headlines for drinking themselves into a stupor, often passing out in the process.

And they’re getting younger: A June 2006 European Union-commissioned report says nearly all 15-to 16-year-old European students have had alcohol at some point in their lives and, on average, now start when they’re just 12 1/2 years old.

The data comes from a 2003 survey by the European School Survey Project on Alcohol and Other Drugs.

More than one in six have “binged” - had five or more drinks on a single occasion - three or more times in the last month, said the report by the London-based Institute of Alcohol Studies. It excluded EU newcomers Bulgaria and Romania.

In contrast to the United States or Canada, where even adults are often asked to prove their age when buying beer and other alcoholic drinks, laws in Europe are more lax and the drinking age generally hovers around 16 or 18.

Supermarkets sell alcohol and, unlike in the U.S., bottles and cans are seldom stashed away in areas that are off-limits to underage customers. Carding is uncommon.

In Austria - where binge drinking is known as “Komatrinken,” or “coma drinking” - a new law prohibits the sale of alcohol to anyone under either 16 or 18, depending on the region, and requires cashiers and establishments to card customers if they have any doubt about their age. Failure to do so can result in fines of up to $5,610 and loss of a liquor licence.

When it comes to coma drinking among young people, we’re dealing with a phenomenon that needs to be battled to the best of our abilities,” Economics Minister Martin Bartenstein said.

Authorities and experts alike acknowledge the issue isn’t going away.

The WHO estimates there are 76.3 million people with alcohol use disorders worldwide.

The experts warn that some barely pubescent juveniles are starting to reach for the bottle sooner.

“We’ve seen a whole series of new trends over the past five to 10 years,” said Michael Musalek, director of the Anton Proksch Institute, a renowned Austrian detox center that claims to be Europe’s largest.

For one, the age of alcohol beginners keeps declining. Today, 11-, 12-, 13-year-olds are already drinking - some on a regular basis,” he said.

Hospital officials notice the same trend.

At Vienna’s General Hospital, up to three teens are admitted each weekend after drinking escapades escalate, often leaving them so intoxicated they become unconscious, pediatrician Zsolt Szepfalusi said. More cases are common during special events, such as the city’s annual Danube Island Fest in the summer, he said.

“The numbers aren’t really up - but we’re seeing a decrease in age,” Szepfalusi said. “Some of our patients are as young as 12.”

It’s not just a big-city problem. Robert Birnbacher, head of pediatrics at a public hospital in the southern Austrian town of Villach, said his clinic sees about one to two cases of young “coma drinkers” every weekend.

“The patients are getting younger and there are more girls among them,” he said.

Vladimir Poznyak, coordinator of the team working on the management of substance abuse in the World Health Organization’s Department of Mental Health and Substance Abuse, confirmed a general decline in age for initial contact with alcohol worldwide.

It’s definitely happening and reflects general cultural changes,” Poznyak said.

The risks of starting to drink early include developing a dependence on alcohol and hampering brain development, he said.

In Germany, where beer is a big part of local culture, authorities are calling on adults to counsel their children to put off their first experiences with alcohol.

In October, the government’s “drug czar,” Sabine Baetzing, said every fourth teenager gets drunk off five or more alcoholic drinks at least once a month. The number of teenagers who ended up hospitalized with alcohol poisoning doubled from 9,500 in 2000 to 19,400 in 2005, she said.

But one expert, while welcoming action to fight alcohol abuse among Austria’s young, cautions against blowing the problem out of proportion.

Alfred Uhl, senior scientist at the Vienna-based Ludwig Boltzmann Institute for Addiction Research, said alcohol consumption in Austria peaked around 1970 and has declined ever since - despite the fact that prices have nose-dived. He warned that hospital statistics may be misleading because alcohol-related diagnoses were made less frequently in the past than they are now.

But Uhl acknowledged that Europe’s young, in general, are adopting adult behaviour earlier than they used to - and that includes drinking.

“Generally speaking, Europe’s youngsters are growing up faster than they used to and in countries such as Austria where alcohol is a part of the going out culture, it would be strange if they didn’t consume alcohol as well,” he said.

On the streets of the Austrian capital, teenagers dispute they drink heavily - but acknowledge alcohol has a presence in their lives.

“I started when I was 15 and like beer and tequila,” said 16-year-old Patrick Settinger, smoking a cigarette on his way home from school.

Source: The Canadian Press, Austria
http://canadianpress.google.com/article/ALeqM5g3fB9g7BnwevWxz-erjPnU3VdYGQ

21 April, 2008. 7:36 AM. Link | Comments: No Comments »

Autism Myth Lives On

Why people continue to blame vaccines, despite evidence to the contrary.

As the brother of an autistic person and a brain scientist, I have been hoping that the increased focus on autism in the news would lead to a greater public understanding of this disorder. Instead, I am angry that this coverage is spreading dangerous myths.

My sister, Karen, is autistic. In the 1970s, my parents wondered why she behaved so differently. At the time, a prevalent idea was that an emotionally distant mother could somehow prevent a child from understanding emotions or relating normally to others. Our parents had a simpler idea, that they might have hurt Karen’s head during a bath.

Both these ideas are wrong. Autism is a neurological disorder, and its signs appear by the age of 1 or even earlier. It is highly inheritable. In identical twins where one is autistic, the chance that both are autistic is greater than 50-50. Even non-identical twins and siblings are at increased risk. In short, I dodged a genetic bullet. Now I worry about my daughter.

A link that isn’t there

Recently, celebrities such as Jenny McCarthy and other activists have taken to the airwaves to repeat the myth that autism is linked to vaccination. Although peer-reviewed scientific evidence overwhelmingly opposes their views, they have attracted attention. In a recent discussion on Larry King Live, three pediatricians invited to make the case for science were no match for McCarthy’s star power. Situations like this could mistakenly persuade parents to leave their children unvaccinated and vulnerable to contagious diseases.

Speculation about a vaccine-autism link began with a 1998 uncontrolled study of a few autistic children. But the conclusions were later retracted. Subsequent speculation focused on the compound thimerosal. But removing it from all routine childhood vaccines in the USA, Denmark, Sweden and Canada has not decreased autism rates.

What are McCarthy’s credentials? She is an actress and comedienne — with an autistic son. Her career took on new life after she wrote a best-selling pregnancy guide. Like all parents of autistic children, she wrestled with the question of what caused his disorder. She recalled that her son was vaccinated about the time his symptoms first appeared. Aha! That’s it. Here is an example of her reasoning: “I believe that parents’ anecdotal information is science-based information.”

How we’re wired

Although her concept of evidence is flawed, I don’t blame her. The error highlights how our brains are wired to think. Like the authors of the 1998 study, she concluded that two events happening around the same time must be linked. They used the principle that coincidence implies a causal link. But there was no coincidence for her son: He was born in 2002, after thimerosal was removed from vaccines.

The problem is compounded by “source amnesia,” in which people are prone to remember a statement without recalling where they heard it or whether the source was reliable. Presidential candidate John McCain might have fallen prey to source amnesia when he repeated the vaccine-autism myth last month. Recollection is more likely when the “fact” fits previously held views; parents might already dislike vaccinations based on their kids’ reaction to shots. But when it comes to a complex issue such as autism, such errors of reasoning hinder us from distinguishing real causes from coincidences.

Out of sight of the cameras, increased research funding is spurring efforts to find autism’s causes. Scientists are vitally interested in possible environmental influences. But the vaccine story is a dry well. Working on it further wastes valuable time and resources. It’s time to dig elsewhere.

As I watch my beautiful 10-month-old daughter grow, I wish that preventing autism were as simple as withholding a few injections. But along with my wife, a physician, I understand the vital importance of vaccination, not only for maintaining our baby’s health but also protecting our community from infectious diseases. Our daughter’s next shots are in two months.

Sam Wang is an associate professor of molecular biology and neuroscience at Princeton University. He is a co-author of Welcome to Your Brain: Why You Lose Your Car Keys But Never Forget How to Drive and Other Puzzles of Everyday Life.

Source: USA Today
http://blogs.usatoday.com/oped/2008/04/autism-myth-liv.html

16 April, 2008. 8:03 AM. Link | Comments: No Comments »

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